Summary: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009].

leucine zipper tumor suppressor 1MIM:606551Ensembl:ENSG00000061337HGNC:HGNC:13861PA305078p21.3

GO terms in LZTS1

Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIMPGO:0016242negative regulation of macroautophagy
BPIEAGO:0044772mitotic cell cycle phase transition
CCIEAGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCIEAGO:0043197dendritic spine
CCIEAGO:0045211postsynaptic membrane
MFNASGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008017microtubule binding

Gene expression in normal tissue: LZTS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LZTS1

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LZTS1