CELF3
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CUGBP Elav-like family member 3 | MIM:612678 | Ensembl:ENSG00000159409 | HGNC:HGNC:11967 | PA36654 | 1q21.3 |
GO terms in CELF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IDA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IBA | GO:0006376 | mRNA splice site selection |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IMP | GO:0008380 | RNA splicing |
| BP | IEA | GO:0030317 | flagellated sperm motility |
| BP | IEA | GO:0030575 | nuclear body organization |
| BP | IDA | GO:0048026 | positive regulation of mRNA splicing, via spliceosome |
| BP | IEA | GO:0098781 | ncRNA transcription |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016604 | nuclear body |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IMP | GO:0003723 | RNA binding |
| MF | IBA | GO:0003729 | mRNA binding |
| MF | NAS | GO:0036002 | pre-mRNA binding |
| MF | IEA | GO:0097322 | 7SK snRNA binding |
Gene expression in normal tissue: CELF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CELF3
CLASSFICATION
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