CELF3
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612678 Ensembl IDEnsembl:ENSG00000159409 HGNC IDHGNC:HGNC:11967 PHARMGKB IDPA36654 Map Location1q21.3 | |||||
GO terms in CELF3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IDA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | IBA | GO:0006376 | mRNA splice site selection |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IMP | GO:0008380 | RNA splicing |
Gene expression in normal tissue: CELF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CELF3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3527 | Preimplantation Embryo |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CELF3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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