CMTM7
Summary: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607890 Ensembl IDEnsembl:ENSG00000153551 HGNC IDHGNC:HGNC:19178 PHARMGKB IDPA38817 Map Location3p22.3 | |||||
GO terms in CMTM7
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005125 | cytokine activity |
| BP | IEA | GO:0002337 | B-1a B cell differentiation |
| BP | IEA | GO:0006935 | chemotaxis |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| CC | IEA | GO:0005615 | extracellular space |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: CMTM7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CMTM7
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CMTM7
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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