STX1B


Summary: The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
syntaxin 1BMIM:601485Ensembl:ENSG00000099365HGNC:HGNC:18539PA3834516p11.2

GO terms in STX1B


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000149SNARE binding
MFIEAGO:0005102signaling receptor binding
MFIBAGO:0005484SNAP receptor activity
MFISSGO:0019901protein kinase binding
MFIEAGO:0019904protein domain specific binding
CCIEAGO:0005634nucleus
CCIEAGO:0005815microtubule organizing center
CCIEAGO:0005819spindle
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0008021synaptic vesicle
CCIBAGO:0012505endomembrane system
CCISSGO:0016020membrane
CCIBAGO:0016021integral component of membrane
CCIEAGO:0030424axon
CCIBAGO:0031201SNARE complex
CCIBAGO:0042734presynaptic membrane
CCIBAGO:0048787presynaptic active zone membrane
CCIEAGO:0048787presynaptic active zone membrane
BPISSGO:0001956positive regulation of neurotransmitter secretion
BPIBAGO:0006886intracellular protein transport
BPIBAGO:0006887exocytosis
BPISSGO:0006904vesicle docking involved in exocytosis
BPIBAGO:0006906vesicle fusion
BPISSGO:0010468regulation of gene expression
BPISSGO:0010807regulation of synaptic vesicle priming
BPISSGO:0010977negative regulation of neuron projection development
BPISSGO:0016081synaptic vesicle docking
BPIBAGO:0031629synaptic vesicle fusion to presynaptic active zone membrane
BPIBAGO:0048278vesicle docking
BPIEAGO:0048791calcium ion-regulated exocytosis of neurotransmitter
BPISSGO:0060025regulation of synaptic activity
BPIEAGO:0061669spontaneous neurotransmitter secretion
BPIBAGO:0098967exocytic insertion of neurotransmitter receptor to postsynaptic membrane
BPIEAGO:0098967exocytic insertion of neurotransmitter receptor to postsynaptic membrane
BPIEAGO:1903422negative regulation of synaptic vesicle recycling
BPIEAGO:1904050positive regulation of spontaneous neurotransmitter secretion
BPISSGO:1905302negative regulation of macropinocytosis
BPISSGO:2000463positive regulation of excitatory postsynaptic potential

Gene expression in normal tissue: STX1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STX1B


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1643685Disease
reactomeR-HSA-168799Neurotoxicity of clostridium toxins
reactomeR-HSA-5250971Toxicity of botulinum toxin type C (BoNT/C)
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5682910LGI-ADAM interactions
pharmgkbPA162355621Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
kegghsa04130SNARE interactions in vesicular transport - Homo sapiens (human)
kegghsa04721Synaptic vesicle cycle - Homo sapiens (human)
wikipathwaysWP2267Synaptic Vesicle Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STX1B

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