KLF12


Summary: Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Kruppel like factor 12MIM:607531Ensembl:ENSG00000118922HGNC:HGNC:6346PA3013213q22.1

GO terms in KLF12


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006357regulation of transcription by RNA polymerase II
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: KLF12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLF12


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLF12

​​​​