MGAT4B
Summary: This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B | MIM:604561 | Ensembl:ENSG00000161013 | HGNC:HGNC:7048 | PA30783 | 5q35.3 |
GO terms in MGAT4B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006487 | protein N-linked glycosylation |
| BP | TAS | GO:0006491 | N-glycan processing |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: MGAT4B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MGAT4B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00510 | N-Glycan biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| reactome | R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi |
| reactome | R-HSA-975577 | N-Glycan antennae elongation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MGAT4B
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