Summary: This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].

CD300a moleculeMIM:606790Ensembl:ENSG00000167851HGNC:HGNC:19319PA14267214917q25.1

GO terms in CD300A

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCHDAGO:0070062extracellular exosome
CCTASGO:0070821tertiary granule membrane
CCTASGO:0101003ficolin-1-rich granule membrane
BPIEAGO:0007155cell adhesion
BPIEAGO:0007165signal transduction
BPIMPGO:0030889negative regulation of B cell proliferation
BPIDAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPIDAGO:0033007negative regulation of mast cell activation involved in immune response
BPIMPGO:0034125negative regulation of MyD88-dependent toll-like receptor signaling pathway
BPIDAGO:0043305negative regulation of mast cell degranulation
BPTASGO:0043312neutrophil degranulation
BPIDAGO:0043407negative regulation of MAP kinase activity
BPIDAGO:0048147negative regulation of fibroblast proliferation
BPTASGO:0050776regulation of immune response
BPIDAGO:0050856regulation of T cell receptor signaling pathway
BPIDAGO:0050859negative regulation of B cell receptor signaling pathway
BPIDAGO:0051134negative regulation of NK T cell activation
BPIMPGO:0060101negative regulation of phagocytosis, engulfment
BPIDAGO:1902564negative regulation of neutrophil activation
BPIDAGO:1902567negative regulation of eosinophil activation
BPIDAGO:1902569negative regulation of activation of Janus kinase activity
BPIDAGO:2000417negative regulation of eosinophil migration
MFIDAGO:0001786phosphatidylserine binding
MFIPIGO:0005515protein binding
MFIDAGO:0008429phosphatidylethanolamine binding
MFIDAGO:0038023signaling receptor activity

Gene expression in normal tissue: CD300A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD300A

DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-6798695Neutrophil degranulation
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD300A