CD300A
Summary: This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD300a molecule | MIM:606790 | Ensembl:ENSG00000167851 | HGNC:HGNC:19319 | PA142672149 | 17q25.1 |
GO terms in CD300A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IMP | GO:0030889 | negative regulation of B cell proliferation |
| BP | IDA | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| BP | IDA | GO:0033007 | negative regulation of mast cell activation involved in immune response |
| BP | IMP | GO:0034125 | negative regulation of MyD88-dependent toll-like receptor signaling pathway |
| BP | IDA | GO:0043305 | negative regulation of mast cell degranulation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IDA | GO:0048147 | negative regulation of fibroblast proliferation |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | IDA | GO:0050856 | regulation of T cell receptor signaling pathway |
| BP | IDA | GO:0050859 | negative regulation of B cell receptor signaling pathway |
| BP | IDA | GO:0051134 | negative regulation of NK T cell activation |
| BP | IMP | GO:0060101 | negative regulation of phagocytosis, engulfment |
| BP | IDA | GO:1902564 | negative regulation of neutrophil activation |
| BP | IDA | GO:1902567 | negative regulation of eosinophil activation |
| BP | IDA | GO:1902569 | negative regulation of activation of Janus kinase activity |
| BP | IDA | GO:2000417 | negative regulation of eosinophil migration |
| MF | IDA | GO:0001786 | phosphatidylserine binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008429 | phosphatidylethanolamine binding |
| MF | IDA | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: CD300A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD300A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD300A
CLASSFICATION
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