PHB2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prohibitin 2 | MIM:610704 | Ensembl:ENSG00000215021 | HGNC:HGNC:30306 | PA142671181 | 12p13.31 |
GO terms in PHB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005741 | mitochondrial outer membrane |
| CC | ISS | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0016363 | nuclear matrix |
| CC | IEA | GO:0030424 | axon |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0071944 | cell periphery |
| BP | IDA | GO:0000060 | protein import into nucleus, translocation |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006851 | mitochondrial calcium ion transmembrane transport |
| BP | IMP | GO:0007005 | mitochondrion organization |
| BP | IDA | GO:0007062 | sister chromatid cohesion |
| BP | IEA | GO:0009611 | response to wounding |
| BP | IDA | GO:0030449 | regulation of complement activation |
| BP | IMP | GO:0031536 | positive regulation of exit from mitosis |
| BP | IEA | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway |
| BP | IEA | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0060744 | mammary gland branching involved in thelarche |
| BP | IEA | GO:0060749 | mammary gland alveolus development |
| BP | IEA | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | HEP | GO:0071277 | cellular response to calcium ion |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IMP | GO:1902808 | positive regulation of cell cycle G1/S phase transition |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | NAS | GO:0030331 | estrogen receptor binding |
| MF | IPI | GO:0033218 | amide binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
Gene expression in normal tissue: PHB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-8949215 | Mitochondrial calcium ion transport |
| reactome | R-HSA-8949664 | Processing of SMDT1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PHB2
CLASSFICATION
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