CHRNB2

Summary: Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecholinergic receptor nicotinic beta 2 subunit
OMIM IDMIM:118507
Ensembl IDEnsembl:ENSG00000160716
HGNC IDHGNC:HGNC:1962
PHARMGKB IDPA115
Map Location1q21.3

GO terms in CHRNB2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC IBA GO:0005892 acetylcholine-gated channel complex
CC IDA GO:0005892 acetylcholine-gated channel complex
CC ISS GO:0009897 external side of plasma membrane
CC NAS GO:0016021 integral component of membrane
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Gene expression in normal tissue: CHRNB2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Protein stability and degradation1ERK MAPK signaling1

Pathways in CHRNB2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
reactome R-HSA-112315 Transmission across Chemical Synapses
reactome R-HSA-112316 Neuronal System
reactome R-HSA-181431 Acetylcholine binding and downstream events
reactome R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
reactome R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHRNB2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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