Summary: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008].

TNF receptor superfamily member 13CMIM:606269Ensembl:ENSG00000159958HGNC:HGNC:17755PA3846622q13.2

GO terms in TNFRSF13C

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
BPIEAGO:0001782B cell homeostasis
BPIEAGO:0002250adaptive immune response
BPIEAGO:0002636positive regulation of germinal center formation
BPIEAGO:0030890positive regulation of B cell proliferation
BPIEAGO:0031295T cell costimulation
BPIEAGO:0031296B cell costimulation
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPIEAGO:0042102positive regulation of T cell proliferation
BPIEAGO:0045078positive regulation of interferon-gamma biosynthetic process

Gene expression in normal tissue: TNFRSF13C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNFRSF13C

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05340Primary immunodeficiency - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFRSF13C