NOSTRIN


Summary: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nitric oxide synthase traffickingMIM:607496Ensembl:ENSG00000163072HGNC:HGNC:20203PA1349927872q24.3

GO terms in NOSTRIN


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005856cytoskeleton
CCTASGO:0005886plasma membrane
CCIDAGO:0016607nuclear speck
CCTASGO:0030666endocytic vesicle membrane
BPIEAGO:0006897endocytosis
BPIEAGO:0045892negative regulation of transcription, DNA-templated
BPTASGO:0050999regulation of nitric-oxide synthase activity
MFIEAGO:0003677DNA binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: NOSTRIN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NOSTRIN


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-202131Metabolism of nitric oxide
reactomeR-HSA-203641NOSTRIN mediated eNOS trafficking
reactomeR-HSA-203765eNOS activation and regulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NOSTRIN

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