NOSTRIN
Summary: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nitric oxide synthase trafficking | MIM:607496 | Ensembl:ENSG00000163072 | HGNC:HGNC:20203 | PA134992787 | 2q24.3 |
GO terms in NOSTRIN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| BP | IEA | GO:0006897 | endocytosis |
| BP | IEA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | TAS | GO:0050999 | regulation of nitric-oxide synthase activity |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: NOSTRIN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NOSTRIN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-202131 | Metabolism of nitric oxide |
| reactome | R-HSA-203641 | NOSTRIN mediated eNOS trafficking |
| reactome | R-HSA-203765 | eNOS activation and regulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NOSTRIN
CLASSFICATION
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