LRG1
Summary: The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| leucine rich alpha-2-glycoprotein 1 | MIM:611289 | Ensembl:ENSG00000171236 | HGNC:HGNC:29480 | PA134919634 | 19p13.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in LRG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0045766 | positive regulation of angiogenesis |
| BP | IEA | GO:0050873 | brown fat cell differentiation |
| CC | HDA | GO:0005576 | extracellular region |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | NAS | GO:0016020 | membrane |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0005160 | transforming growth factor beta receptor binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: LRG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRG1
CLASSFICATION
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