LRG1

Summary: The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameleucine rich alpha-2-glycoprotein 1
OMIM IDMIM:611289
Ensembl IDEnsembl:ENSG00000171236
HGNC IDHGNC:HGNC:29480
PHARMGKB IDPA134919634
Map Location19p13.3

Gene Categories:

DRUGGABLE GENOME

GO terms in LRG1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001938 positive regulation of endothelial cell proliferation
BP ND GO:0008150 biological_process
BP IEA GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
BP TAS GO:0043312 neutrophil degranulation
BP IEA GO:0045766 positive regulation of angiogenesis
BP IEA GO:0050873 brown fat cell differentiation
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Gene expression in normal tissue: LRG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LRG1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-6798695 Neutrophil degranulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRG1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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