MED12L
Summary: The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611318 Ensembl IDEnsembl:ENSG00000144893 HGNC IDHGNC:HGNC:16050 PHARMGKB IDPA134884590 Map Location3q25.1 | |||||
GO terms in MED12L
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0008013 | beta-catenin binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0016592 | mediator complex |
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Gene expression in normal tissue: MED12L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MED12L
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MED12L
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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