Summary: This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

ANTXR cell adhesion molecule 2MIM:608041Ensembl:ENSG00000163297HGNC:HGNC:21732PA1283947524q21.21

GO terms in ANTXR2

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0007165signal transduction
BPIEAGO:0007165signal transduction
BPIEAGO:0022414reproductive process
BPIBAGO:1901998toxin transport
BPIEAGO:1901998toxin transport
CCIEAGO:0005576extracellular region
CCIEAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIBAGO:0009986cell surface
CCTASGO:0010008endosome membrane
CCIEAGO:0016021integral component of membrane
MFIBAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0038023signaling receptor activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ANTXR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ANTXR2

DatabasePathway IDPathway Des.
reactomeR-HSA-5210891Uptake and function of anthrax toxins
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663205Infectious disease
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
pidanthraxpathwayCellular roles of Anthrax toxin

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANTXR2