CLIC1


Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
chloride intracellular channel 1MIM:602872Ensembl:ENSG00000213719HGNC:HGNC:2062PA265886p21.33

GO terms in CLIC1


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005615extracellular space
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005635nuclear envelope
CCHDAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIEAGO:0005886plasma membrane
CCTASGO:0005903brush border
CCHDAGO:0016020membrane
CCIEAGO:0031965nuclear membrane
CCHDAGO:0031982vesicle
CCIEAGO:0034707chloride channel complex
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCIDAGO:0070062extracellular exosome
CCHDAGO:0072562blood microparticle
BPIDAGO:0006821chloride transport
BPTASGO:0007165signal transduction
BPIEAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0045669positive regulation of osteoblast differentiation
BPIEAGO:0051726regulation of cell cycle
BPIEAGO:0051881regulation of mitochondrial membrane potential
BPHMPGO:0070527platelet aggregation
BPIEAGO:1902476chloride transmembrane transport
MFIEAGO:0005244voltage-gated ion channel activity
MFIBAGO:0005254chloride channel activity
MFIDAGO:0005254chloride channel activity
MFIPIGO:0005515protein binding
MFHDAGO:0045296cadherin binding

Gene expression in normal tissue: CLIC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLIC1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLIC1

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