CLIC1
Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chloride intracellular channel 1 | MIM:602872 | Ensembl:ENSG00000213719 | HGNC:HGNC:2062 | PA26588 | 6p21.33 |
GO terms in CLIC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | HDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005903 | brush border |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0031965 | nuclear membrane |
| CC | HDA | GO:0031982 | vesicle |
| CC | IEA | GO:0034707 | chloride channel complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | HDA | GO:0072562 | blood microparticle |
| BP | IDA | GO:0006821 | chloride transport |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0051881 | regulation of mitochondrial membrane potential |
| BP | HMP | GO:0070527 | platelet aggregation |
| BP | IEA | GO:1902476 | chloride transmembrane transport |
| MF | IEA | GO:0005244 | voltage-gated ion channel activity |
| MF | IBA | GO:0005254 | chloride channel activity |
| MF | IDA | GO:0005254 | chloride channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: CLIC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLIC1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLIC1
CLASSFICATION
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