SOCS4
Summary: The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| suppressor of cytokine signaling 4 | MIM:616337 | Ensembl:ENSG00000180008 | HGNC:HGNC:19392 | PA164742477 | 14q22.3 |
GO terms in SOCS4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0040008 | regulation of growth |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SOCS4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SOCS4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| wikipathways | WP1584 | Type II diabetes mellitus |
| wikipathways | WP4105 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOCS4
CLASSFICATION
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