ABCC2
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATP binding cassette subfamily C member 2 | MIM:601107 | Ensembl:ENSG00000023839 | HGNC:HGNC:53 | PA116 | 10q24.2 |
GO terms in ABCC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IBA | GO:0016020 | membrane |
| CC | IBA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0031526 | brush border membrane |
| CC | IEA | GO:0046581 | intercellular canaliculus |
| BP | IEA | GO:0006855 | drug transmembrane transport |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0009408 | response to heat |
| BP | IEA | GO:0015694 | mercury ion transport |
| BP | IEA | GO:0015722 | canalicular bile acid transport |
| BP | IEA | GO:0015723 | bilirubin transport |
| BP | IEA | GO:0015732 | prostaglandin transport |
| BP | IEA | GO:0030644 | cellular chloride ion homeostasis |
| BP | IEA | GO:0031427 | response to methotrexate |
| BP | IEA | GO:0033762 | response to glucagon |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IEA | GO:0046685 | response to arsenic-containing substance |
| BP | IBA | GO:0055085 | transmembrane transport |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | IEA | GO:0070327 | thyroid hormone transport |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071347 | cellular response to interleukin-1 |
| BP | IEA | GO:0071354 | cellular response to interleukin-6 |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IEA | GO:0099133 | ATP hydrolysis coupled anion transmembrane transport |
| BP | IEA | GO:1901086 | benzylpenicillin metabolic process |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008514 | organic anion transmembrane transporter activity |
| MF | TAS | GO:0015127 | bilirubin transmembrane transporter activity |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | TAS | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | TAS | GO:0043225 | ATPase-coupled anion transmembrane transporter activity |
Gene expression in normal tissue: ABCC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA145011109 | Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011110 | Pravastatin Pathway, Pharmacokinetics |
| pharmgkb | PA146123006 | Codeine and Morphine Pathway, Pharmacokinetics |
| pharmgkb | PA150642262 | Platinum Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
| pharmgkb | PA165292163 | Doxorubicin Pathway (Cancer Cell), Pharmacodynamics |
| pharmgkb | PA165292177 | Doxorubicin Pathway, Pharmacokinetics |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| pharmgkb | PA165817070 | Carbamazepine Pathway, Pharmacokinetics |
| pharmgkb | PA165860384 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165946349 | Tramadol Pharmacokinetics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA166041114 | Ibuprofen Pathway, Pharmacokinetics |
| pharmgkb | PA2001 | Irinotecan Pathway, Pharmacokinetics |
| pharmgkb | PA2029 | Irinotecan Pathway, Pharmacodynamics |
| kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| smpdb | SMP00433 | Irinotecan Action Pathway |
| smpdb | SMP00434 | Paclitaxel Action Pathway |
| smpdb | SMP00435 | Docetaxel Action Pathway |
| smpdb | SMP00436 | Vinblastine Action Pathway |
| smpdb | SMP00437 | Vincristine Action Pathway |
| smpdb | SMP00438 | Vindesine Action Pathway |
| smpdb | SMP00439 | Vinorelbine Action Pathway |
| smpdb | SMP00600 | Irinotecan Metabolism Pathway |
| smpdb | SMP00637 | Tramadol Metabolism Pathway |
| smpdb | SMP00649 | Lamivudine Metabolism Pathway |
| smpdb | SMP00650 | Doxorubicin Metabolism Pathway |
| smpdb | SMP00652 | Mycophenolic Acid Metabolism Pathway |
| wikipathways | WP1604 | Codeine and Morphine Metabolism |
| wikipathways | WP2289 | Drug Induction of Bile Acid Pathway |
| wikipathways | WP229 | Irinotecan Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP4010 | Liver steatosis AOP |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
| reactome | R-HSA-5619084 | ABC transporter disorders |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-5679001 | Defective ABCC2 causes Dubin-Johnson syndrome |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCC2
CLASSFICATION
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