CPT1C
Summary: This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608846 Ensembl IDEnsembl:ENSG00000169169 HGNC IDHGNC:HGNC:18540 PHARMGKB IDPA134922321 Map Location19q13.33 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in CPT1C
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004095 | carnitine O-palmitoyltransferase activity |
| MF | IEA | GO:0004095 | carnitine O-palmitoyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008374 | O-acyltransferase activity |
| BP | IBA | GO:0006631 | fatty acid metabolic process |
| BP | IEA | GO:0006635 | fatty acid beta-oxidation |
Gene expression in normal tissue: CPT1C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPT1C
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPT1C
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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