CPT1C
Summary: This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| carnitine palmitoyltransferase 1C | MIM:608846 | Ensembl:ENSG00000169169 | HGNC:HGNC:18540 | PA134922321 | 19q13.33 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CPT1C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004095 | carnitine O-palmitoyltransferase activity |
| MF | IEA | GO:0004095 | carnitine O-palmitoyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008374 | O-acyltransferase activity |
| BP | IBA | GO:0006631 | fatty acid metabolic process |
| BP | IEA | GO:0006635 | fatty acid beta-oxidation |
| BP | IBA | GO:0009437 | carnitine metabolic process |
| BP | IEA | GO:0009437 | carnitine metabolic process |
| BP | IBA | GO:0015909 | long-chain fatty acid transport |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IEA | GO:0032281 | AMPA glutamate receptor complex |
| CC | IEA | GO:0045202 | synapse |
Gene expression in normal tissue: CPT1C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPT1C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| humancyc | PWY-6111 | mitochondrial L-carnitine shuttle |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP3942 | PPAR signaling pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPT1C
CLASSFICATION
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