COMT


Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
catechol-O-methyltransferaseMIM:116790Ensembl:ENSG00000093010HGNC:HGNC:2228PA11722q11.21

GO terms in COMT


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFIPIGO:0005515protein binding
MFTASGO:0008168methyltransferase activity
MFIBAGO:0008171O-methyltransferase activity
MFTASGO:0008171O-methyltransferase activity
MFIBAGO:0016206catechol O-methyltransferase activity
MFIDAGO:0016206catechol O-methyltransferase activity
MFTASGO:0016206catechol O-methyltransferase activity
MFIEAGO:0102084L-dopa O-methyltransferase activity
MFIEAGO:0102938orcinol O-methyltransferase activity
BPIEAGO:0007565female pregnancy
BPIEAGO:0007612learning
BPIEAGO:0007614short-term memory
BPIEAGO:0008210estrogen metabolic process
BPIEAGO:0014070response to organic cyclic compound
BPIEAGO:0016036cellular response to phosphate starvation
BPTASGO:0032259methylation
BPIEAGO:0032496response to lipopolysaccharide
BPIBAGO:0032502developmental process
BPIEAGO:0032502developmental process
BPIEAGO:0035814negative regulation of renal sodium excretion
BPIEAGO:0042135neurotransmitter catabolic process
BPIBAGO:0042417dopamine metabolic process
BPIEAGO:0042420dopamine catabolic process
BPIBAGO:0042424catecholamine catabolic process
BPIDAGO:0042424catecholamine catabolic process
BPIEAGO:0042493response to drug
BPIEAGO:0043627response to estrogen
BPIEAGO:0045963negative regulation of dopamine metabolic process
BPIEAGO:0048265response to pain
BPIEAGO:0048609multicellular organismal reproductive process
BPIEAGO:0048662negative regulation of smooth muscle cell proliferation
BPIEAGO:0050668positive regulation of homocysteine metabolic process
BPIEAGO:0051930regulation of sensory perception of pain
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIBAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0030424axon
CCIEAGO:0030424axon
CCIBAGO:0030425dendrite
CCIEAGO:0043197dendritic spine
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0044297cell body
CCIEAGO:0045211postsynaptic membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: COMT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COMT


DatabasePathway IDPathway Des.
reactomeR-HSA-112311Neurotransmitter clearance
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156580Phase II - Conjugation of compounds
reactomeR-HSA-156581Methylation
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-379397Enzymatic degradation of dopamine by COMT
reactomeR-HSA-379398Enzymatic degradation of Dopamine by monoamine oxidase
reactomeR-HSA-379401Dopamine clearance from the synaptic cleft
humancycPWY-6334L-dopa degradation
humancycPWY-6342noradrenaline and adrenaline degradation
humancycPWY6666-2dopamine degradation
pharmgkbPA145011115Phenytoin Pathway, Pharmacokinetics
pharmgkbPA145011118Estrogen Metabolism Pathway
kegghsa00140Steroid hormone biosynthesis - Homo sapiens (human)
kegghsa00350Tyrosine metabolism - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
wikipathwaysWP2436Dopamine metabolism
wikipathwaysWP550Biogenic Amine Synthesis
wikipathwaysWP697Estrogen metabolism
wikipathwaysWP702Metapathway biotransformation Phase I and II
wikipathwaysWP704Methylation Pathways
smpdbSMP00006Tyrosine Metabolism
smpdbSMP00169Alkaptonuria
smpdbSMP00190Hawkinsinuria
smpdbSMP00218Tyrosinemia Type I
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00429Disulfiram Action Pathway
smpdbSMP00494Tyrosinemia, transient, of the newborn
smpdbSMP00498Dopamine beta-hydroxylase deficiency
smpdbSMP00533Monoamine oxidase-a deficiency (MAO-A)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD185DMOG1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COMT

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