MAP3K8
Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 8 | MIM:191195 | Ensembl:ENSG00000107968 | HGNC:HGNC:6860 | PA30606 | 10p11.23 |
GO terms in MAP3K8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | TAS | GO:0051403 | stress-activated MAPK cascade |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: MAP3K8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| pid | tcrraspathway | Ras signaling in the CD4+ TCR pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
| biocarta | mapkpathway | mapkinase signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| reactome | R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD6 | AM-580 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K8
CLASSFICATION
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