MAP3K8


Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in MAP3K8


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
BP IEA GO:0000186 activation of MAPKK activity
BP TAS GO:0006468 protein phosphorylation
BP IEA GO:0007049 cell cycle
Showing 1 to 6 of 18 rows rows per page

Gene expression in normal tissue: MAP3K8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K8


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP1449 Regulation of toll-like receptor signaling pathway
wikipathways WP2002 miR-targeted genes in epithelium - TarBase
wikipathways WP2003 miR-targeted genes in leukocytes - TarBase
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
wikipathways WP2006 miR-targeted genes in squamous cell - TarBase
wikipathways WP231 TNF alpha Signaling Pathway
Showing 1 to 6 of 78 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD61 Kinetin riboside 3
iGMDRD367 Ro 28-1675 3
iGMDRD871 BRD6368 6
iGMDRD872 BRD7137 1
Showing 1 to 4 of 13 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K8

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​