MAP3K8


Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase kinase 8MIM:191195Ensembl:ENSG00000107968HGNC:HGNC:6860PA3060610p11.23

GO terms in MAP3K8


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIEAGO:0000186activation of MAPKK activity
BPTASGO:0006468protein phosphorylation
BPIEAGO:0007049cell cycle
BPIBAGO:0007346regulation of mitotic cell cycle
BPIBAGO:0023014signal transduction by protein phosphorylation
BPTASGO:0031295T cell costimulation
BPIBAGO:0032147activation of protein kinase activity
BPTASGO:0051403stress-activated MAPK cascade
BPTASGO:0070498interleukin-1-mediated signaling pathway
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004709MAP kinase kinase kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: MAP3K8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K8


DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtcrjnkpathwayJNK signaling in the CD4+ TCR pathway
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
netpathPathway_TNFalphaTNFalpha
biocartamapkpathwaymapkinase signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside3
iGMDRD367Ro 28-16753
iGMDRD871BRD63686
iGMDRD872BRD71371
iGMDRD60Quinoclamine6
iGMDRD255SB2250023
iGMDRD579PF7503
iGMDRD137Indisulam3
iGMDRD271Brefeldin A3
iGMDRD441TW 371
iGMDRD318PAC-16
iGMDRD77Itraconazole3
iGMDRD6AM-5803

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K8

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