WDR36
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WD repeat domain 36 | MIM:609669 | Ensembl:ENSG00000134987 | HGNC:HGNC:30696 | PA134933637 | 5q22.1 |
GO terms in WDR36
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| BP | IEA | GO:0001895 | retina homeostasis |
| BP | IBA | GO:0006364 | rRNA processing |
| BP | TAS | GO:0006364 | rRNA processing |
| BP | IEA | GO:0007601 | visual perception |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0030516 | regulation of axon extension |
| BP | IEA | GO:0050896 | response to stimulus |
| CC | ND | GO:0005575 | cellular_component |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0032040 | small-subunit processome |
| CC | IBA | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome |
Gene expression in normal tissue: WDR36
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WDR36
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6790901 | rRNA modification in the nucleus and cytosol |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WDR36
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.