WDR36
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609669 Ensembl IDEnsembl:ENSG00000134987 HGNC IDHGNC:HGNC:30696 PHARMGKB IDPA134933637 Map Location5q22.1 | |||||
GO terms in WDR36
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| BP | IEA | GO:0001895 | retina homeostasis |
| BP | IBA | GO:0006364 | rRNA processing |
| BP | TAS | GO:0006364 | rRNA processing |
| BP | IEA | GO:0007601 | visual perception |
| BP | ND | GO:0008150 | biological_process |
Gene expression in normal tissue: WDR36
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WDR36
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6790901 | rRNA modification in the nucleus and cytosol |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WDR36
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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