ADORA2B


Summary: This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:600446
PHARMGKB IDPA24585
Map Location17p12

GO terms in ADORA2B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001609 G-protein coupled adenosine receptor activity
CC IEA GO:0005622 intracellular
CC TAS GO:0005886 plasma membrane
CC TAS GO:0005887 integral component of plasma membrane
BP TAS GO:0000187 activation of MAPK activity
BP IEA GO:0001973 adenosine receptor signaling pathway
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Gene expression in normal tissue: ADORA2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADORA2B


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-417973 Adenosine P1 receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADORA2B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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