ADORA2B
Summary: This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adenosine A2b receptor | MIM:600446 | Ensembl:ENSG00000170425 | HGNC:HGNC:264 | PA24585 | 17p12 |
GO terms in ADORA2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001609 | G-protein coupled adenosine receptor activity |
| CC | IEA | GO:0005622 | intracellular |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001973 | adenosine receptor signaling pathway |
| BP | IEA | GO:0002882 | positive regulation of chronic inflammatory response to non-antigenic stimulus |
| BP | TAS | GO:0006968 | cellular defense response |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007190 | activation of adenylate cyclase activity |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | TAS | GO:0007588 | excretion |
| BP | IEA | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IEA | GO:0031284 | positive regulation of guanylate cyclase activity |
| BP | IEA | GO:0031668 | cellular response to extracellular stimulus |
| BP | IEA | GO:0032722 | positive regulation of chemokine production |
| BP | IEA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IEA | GO:0043306 | positive regulation of mast cell degranulation |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0060087 | relaxation of vascular smooth muscle |
Gene expression in normal tissue: ADORA2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADORA2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-417973 | Adenosine P1 receptors |
| reactome | R-HSA-418038 | Nucleotide-like (purinergic) receptors |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-5683826 | Surfactant metabolism |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| wikipathways | WP80 | Nucleotide GPCRs |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| pid | cmyb_pathway | C-MYB transcription factor network |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADORA2B
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.