CR2
Summary: This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:120650 Ensembl IDEnsembl:ENSG00000117322 HGNC IDHGNC:HGNC:2336 PHARMGKB IDPA26857 Map Location1q32.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in CR2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0001848 | complement binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | NAS | GO:0004875 | complement receptor activity |
| MF | NAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: CR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CR2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-166658 | Complement cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-977606 | Regulation of Complement cascade |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2806 | Human Complement System |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CR2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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