PARP1
Summary: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| poly(ADP-ribose) polymerase 1 | MIM:173870 | Ensembl:ENSG00000143799 | HGNC:HGNC:270 | PA32 | 1q42.12 |
GO terms in PARP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0032993 | protein-DNA complex |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000715 | nucleotide-excision repair, DNA damage recognition |
| BP | TAS | GO:0000723 | telomere maintenance |
| BP | TAS | GO:0000724 | double-strand break repair via homologous recombination |
| BP | TAS | GO:0006281 | DNA repair |
| BP | TAS | GO:0006293 | nucleotide-excision repair, preincision complex stabilization |
| BP | TAS | GO:0006294 | nucleotide-excision repair, preincision complex assembly |
| BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| BP | IMP | GO:0006302 | double-strand break repair |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0006471 | protein ADP-ribosylation |
| BP | IMP | GO:0006471 | protein ADP-ribosylation |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0007005 | mitochondrion organization |
| BP | IEA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0010332 | response to gamma radiation |
| BP | ISS | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IEA | GO:0010990 | regulation of SMAD protein complex assembly |
| BP | IEA | GO:0016540 | protein autoprocessing |
| BP | IDA | GO:0018312 | peptidyl-serine ADP-ribosylation |
| BP | IEA | GO:0023019 | signal transduction involved in regulation of gene expression |
| BP | TAS | GO:0030225 | macrophage differentiation |
| BP | IMP | GO:0032042 | mitochondrial DNA metabolic process |
| BP | IDA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway |
| BP | TAS | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | IMP | GO:0034599 | cellular response to oxidative stress |
| BP | IMP | GO:0034644 | cellular response to UV |
| BP | IMP | GO:0036211 | protein modification process |
| BP | IEA | GO:0042769 | DNA damage response, detection of DNA damage |
| BP | IMP | GO:0043504 | mitochondrial DNA repair |
| BP | IEA | GO:0044030 | regulation of DNA methylation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0050790 | regulation of catalytic activity |
| BP | IEA | GO:0051901 | positive regulation of mitochondrial depolarization |
| BP | IEA | GO:0060391 | positive regulation of SMAD protein signal transduction |
| BP | IDA | GO:0070212 | protein poly-ADP-ribosylation |
| BP | TAS | GO:0070911 | global genome nucleotide-excision repair |
| BP | IEA | GO:0071294 | cellular response to zinc ion |
| BP | IEA | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IEA | GO:1901216 | positive regulation of neuron death |
| BP | IEA | GO:1903376 | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| BP | IGI | GO:1903518 | positive regulation of single strand break repair |
| BP | IMP | GO:1903827 | regulation of cellular protein localization |
| BP | IEA | GO:1904044 | response to aldosterone |
| BP | ISS | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| BP | IEA | GO:1904646 | cellular response to amyloid-beta |
| BP | IEA | GO:1904762 | positive regulation of myofibroblast differentiation |
| BP | IDA | GO:1990966 | ATP generation from poly-ADP-D-ribose |
| BP | IEA | GO:2000679 | positive regulation of transcription regulatory region DNA binding |
| BP | IMP | GO:2001170 | negative regulation of ATP biosynthetic process |
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | IMP | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | TAS | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0030331 | estrogen receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0042826 | histone deacetylase binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | IEA | GO:0051287 | NAD binding |
| MF | IEA | GO:0070412 | R-SMAD binding |
| MF | IDA | GO:1990404 | protein ADP-ribosylase activity |
Gene expression in normal tissue: PARP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PARP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair |
| reactome | R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5696394 | DNA Damage Recognition in GG-NER |
| reactome | R-HSA-5696395 | Formation of Incision Complex in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-5696400 | Dual Incision in GG-NER |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73884 | Base Excision Repair |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73933 | Resolution of Abasic Sites (AP sites) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| biocarta | aifpathway | opposing roles of aif in apoptosis and cell survival |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| kegg | hsa03410 | Base excision repair - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2513 | Nanoparticle triggered regulated necrosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3630 | NAD metabolism, sirtuins and aging |
| wikipathways | WP3644 | NAD+ metabolism |
| wikipathways | WP3645 | NAD+ biosynthetic pathways |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD12 | Bicalutamide | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD474 | Avrainvillamide | 6 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD352 | PD-0325901 | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD78 | Topotecan | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD318 | PAC-1 | 8 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD613 | CHEMBL258148 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD886 | Compound 1541A | 6 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD271 | Brefeldin A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PARP1
CLASSFICATION
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