PARP1


Summary: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
poly(ADP-ribose) polymerase 1MIM:173870Ensembl:ENSG00000143799HGNC:HGNC:270PA321q42.12

GO terms in PARP1


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0005634nucleus
CCIDAGO:0005635nuclear envelope
CCTASGO:0005654nucleoplasm
CCIDAGO:0005667transcription factor complex
CCIDAGO:0005730nucleolus
CCIDAGO:0005739mitochondrion
CCHDAGO:0016020membrane
CCIDAGO:0032991protein-containing complex
CCIDAGO:0032993protein-DNA complex
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0000715nucleotide-excision repair, DNA damage recognition
BPTASGO:0000723telomere maintenance
BPTASGO:0000724double-strand break repair via homologous recombination
BPTASGO:0006281DNA repair
BPTASGO:0006293nucleotide-excision repair, preincision complex stabilization
BPTASGO:0006294nucleotide-excision repair, preincision complex assembly
BPTASGO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion
BPIMPGO:0006302double-strand break repair
BPTASGO:0006366transcription by RNA polymerase II
BPIDAGO:0006471protein ADP-ribosylation
BPIMPGO:0006471protein ADP-ribosylation
BPIDAGO:0006915apoptotic process
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0007005mitochondrion organization
BPIEAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0010332response to gamma radiation
BPISSGO:0010613positive regulation of cardiac muscle hypertrophy
BPIEAGO:0010990regulation of SMAD protein complex assembly
BPIEAGO:0016540protein autoprocessing
BPIDAGO:0018312peptidyl-serine ADP-ribosylation
BPIEAGO:0023019signal transduction involved in regulation of gene expression
BPTASGO:0030225macrophage differentiation
BPIMPGO:0032042mitochondrial DNA metabolic process
BPIDAGO:0032869cellular response to insulin stimulus
BPIEAGO:0033148positive regulation of intracellular estrogen receptor signaling pathway
BPTASGO:0033683nucleotide-excision repair, DNA incision
BPIMPGO:0034599cellular response to oxidative stress
BPIMPGO:0034644cellular response to UV
BPIMPGO:0036211protein modification process
BPIEAGO:0042769DNA damage response, detection of DNA damage
BPIMPGO:0043504mitochondrial DNA repair
BPIEAGO:0044030regulation of DNA methylation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0050790regulation of catalytic activity
BPIEAGO:0051901positive regulation of mitochondrial depolarization
BPIEAGO:0060391positive regulation of SMAD protein signal transduction
BPIDAGO:0070212protein poly-ADP-ribosylation
BPTASGO:0070911global genome nucleotide-excision repair
BPIEAGO:0071294cellular response to zinc ion
BPIEAGO:1900182positive regulation of protein localization to nucleus
BPIEAGO:1901216positive regulation of neuron death
BPIEAGO:1903376regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
BPIGIGO:1903518positive regulation of single strand break repair
BPIMPGO:1903827regulation of cellular protein localization
BPIEAGO:1904044response to aldosterone
BPISSGO:1904357negative regulation of telomere maintenance via telomere lengthening
BPIEAGO:1904646cellular response to amyloid-beta
BPIEAGO:1904762positive regulation of myofibroblast differentiation
BPIDAGO:1990966ATP generation from poly-ADP-D-ribose
BPIEAGO:2000679positive regulation of transcription regulatory region DNA binding
BPIMPGO:2001170negative regulation of ATP biosynthetic process
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFHDAGO:0003723RNA binding
MFIDAGO:0003950NAD+ ADP-ribosyltransferase activity
MFIMPGO:0003950NAD+ ADP-ribosyltransferase activity
MFTASGO:0003950NAD+ ADP-ribosyltransferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019901protein kinase binding
MFIEAGO:0030331estrogen receptor binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0042826histone deacetylase binding
MFIPIGO:0047485protein N-terminus binding
MFIEAGO:0051287NAD binding
MFIEAGO:0070412R-SMAD binding
MFIDAGO:1990404protein ADP-ribosylase activity

Gene expression in normal tissue: PARP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PARP1


DatabasePathway IDPathway Des.
reactomeR-HSA-110362POLB-Dependent Long Patch Base Excision Repair
reactomeR-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108214SUMOylation of DNA damage response and repair proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5685939HDR through MMEJ (alt-NHEJ)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5696394DNA Damage Recognition in GG-NER
reactomeR-HSA-5696395Formation of Incision Complex in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-5696400Dual Incision in GG-NER
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73884Base Excision Repair
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73933Resolution of Abasic Sites (AP sites)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006936Signaling by TGF-beta family members
biocartaaifpathwayopposing roles of aif in apoptosis and cell survival
biocartacaspasepathwaycaspase cascade in apoptosis
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
kegghsa03410Base excision repair - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidhes_heypathwayNotch-mediated HES/HEY network
pidilk_pathwayIntegrin-linked kinase signaling
netpathPathway_AndrogenReceptorAndrogenReceptor
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2513Nanoparticle triggered regulated necrosis
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3630NAD metabolism, sirtuins and aging
wikipathwaysWP3644NAD+ metabolism
wikipathwaysWP3645NAD+ biosynthetic pathways
wikipathwaysWP3980Protein alkylation leading to liver fibrosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside5
iGMDRD152179324-69-71
iGMDRD546BMS-7548074
iGMDRD781Sirolimus5
iGMDRD76Simvastatin1
iGMDRD126Tipifarnib5
iGMDRD151CHM-11
iGMDRD12Bicalutamide2
iGMDRD420Leucascandrolide A3
iGMDRD874BRD89581
iGMDRD23Gossypol2
iGMDRD399Selumetinib1
iGMDRD888Compound 443
iGMDRD780PP-302
iGMDRD284Palbociclib1
iGMDRD226ML0062
iGMDRD294Batimastat2
iGMDRD474Avrainvillamide6
iGMDRD260FQI-23
iGMDRD511CHEMBL3993792
iGMDRD341Triacsin c2
iGMDRD352PD-03259012
iGMDRD560MK-22062
iGMDRD79Gemcitabine2
iGMDRD324CI-10401
iGMDRD322FK 8666
iGMDRD871BRD63682
iGMDRD329Merck604
iGMDRD705Nakiterpiosin3
iGMDRD213SMR0000686503
iGMDRD103SN-382
iGMDRD251ML1622
iGMDRD121GMX17786
iGMDRD467Motesanib1
iGMDRD634SCHEMBL26080412
iGMDRD498GW441756X1
iGMDRD78Topotecan1
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD112Methotrexate1
iGMDRD97Bexarotene1
iGMDRD599Salermide2
iGMDRD268Cerulenin1
iGMDRD573GSK-1904529A1
iGMDRD782DC-45-A26
iGMDRD318PAC-18
iGMDRD870BRD636103
iGMDRD255SB2250021
iGMDRD613CHEMBL2581482
iGMDRD211(1S,3R)-RSL32
iGMDRD351GW843682X4
iGMDRD116CD4373
iGMDRD84Lovastatin acid3
iGMDRD307Manumycin A2
iGMDRD512nutlin 34
iGMDRD148Pifithrin-mu3
iGMDRD505Pevonedistat4
iGMDRD886Compound 1541A6
iGMDRD353PD03259012
iGMDRD872BRD71374
iGMDRD6AM-5804
iGMDRD434BMS-5369243
iGMDRD459RO-33061
iGMDRD267Oligomycin A4
iGMDRD271Brefeldin A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PARP1

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