SESN3


Summary: This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sestrin 3MIM:607768Ensembl:ENSG00000149212HGNC:HGNC:23060PA13491498311q21

GO terms in SESN3


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0016491oxidoreductase activity
MFIBAGO:0016684oxidoreductase activity, acting on peroxide as acceptor
MFIBAGO:0070728leucine binding
CCIEAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIBAGO:0031932TORC2 complex
CCIEAGO:0031932TORC2 complex
CCIBAGO:0061700GATOR2 complex
CCIDAGO:0061700GATOR2 complex
BPIBAGO:0016239positive regulation of macroautophagy
BPIEAGO:0032868response to insulin
BPIMPGO:0034198cellular response to amino acid starvation
BPIEAGO:0038203TORC2 signaling
BPIMPGO:0042149cellular response to glucose starvation
BPIEAGO:0042593glucose homeostasis
BPIEAGO:0046626regulation of insulin receptor signaling pathway
BPIEAGO:0051896regulation of protein kinase B signaling
BPIEAGO:0055114oxidation-reduction process
BPIBAGO:0071230cellular response to amino acid stimulus
BPIEAGO:0071230cellular response to amino acid stimulus
BPIBAGO:0071233cellular response to leucine
BPIEAGO:1901031regulation of response to reactive oxygen species
BPIBAGO:1904262negative regulation of TORC1 signaling
BPIMPGO:1904262negative regulation of TORC1 signaling
BPIBAGO:1990253cellular response to leucine starvation

Gene expression in normal tissue: SESN3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SESN3


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
wikipathwaysWP3349TP53 Regulates Metabolic Genes
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SESN3

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