CSNK1D
Summary: This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| casein kinase 1 delta | MIM:600864 | Ensembl:ENSG00000141551 | HGNC:HGNC:2452 | PA26952 | 17q25.3 |
GO terms in CSNK1D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | ISS | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0042277 | peptide binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0050321 | tau-protein kinase activity |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0007020 | microtubule nucleation |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | IMP | GO:0034067 | protein localization to Golgi apparatus |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | TAS | GO:0048208 | COPII vesicle coating |
| BP | IDA | GO:0051225 | spindle assembly |
| BP | IMP | GO:0061512 | protein localization to cilium |
| BP | IMP | GO:0071539 | protein localization to centrosome |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IC | GO:1905426 | positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| BP | IMP | GO:1905515 | non-motile cilium assembly |
| BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | ISS | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005819 | spindle |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: CSNK1D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSNK1D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| biocarta | ck1pathway | regulation of ck1/cdk5 by type 1 glutamate receptors |
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | foxopathway | FoxO family signaling |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | p53regulationpathway | p53 pathway |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD889 | Compound 7d-cis | 10 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSNK1D
CLASSFICATION
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