APCDD1

Summary: This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameAPC down-regulated 1
OMIM IDMIM:607479
Ensembl IDEnsembl:ENSG00000154856
HGNC IDHGNC:HGNC:15718
PHARMGKB IDPA24876
Map Location18p11.22

GO terms in APCDD1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IDA GO:0017147 Wnt-protein binding
MF IPI GO:0042802 identical protein binding
CC IDA GO:0005887 integral component of plasma membrane
BP IMP GO:0001942 hair follicle development
BP IEA GO:0016055 Wnt signaling pathway
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Gene expression in normal tissue: APCDD1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in APCDD1


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in APCDD1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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