APCDD1


Summary: This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
APC down-regulated 1MIM:607479Ensembl:ENSG00000154856HGNC:HGNC:15718PA2487618p11.22

GO terms in APCDD1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0017147Wnt-protein binding
MFIPIGO:0042802identical protein binding
CCIDAGO:0005887integral component of plasma membrane
BPIMPGO:0001942hair follicle development
BPIEAGO:0016055Wnt signaling pathway
BPIDAGO:0030178negative regulation of Wnt signaling pathway
BPIEAGO:0043615astrocyte cell migration

Gene expression in normal tissue: APCDD1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in APCDD1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in APCDD1

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