APCDD1
Summary: This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
APC down-regulated 1 | MIM:607479 | Ensembl:ENSG00000154856 | HGNC:HGNC:15718 | PA24876 | 18p11.22 |
GO terms in APCDD1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0017147 | Wnt-protein binding |
MF | IPI | GO:0042802 | identical protein binding |
CC | IDA | GO:0005887 | integral component of plasma membrane |
BP | IMP | GO:0001942 | hair follicle development |
BP | IEA | GO:0016055 | Wnt signaling pathway |
BP | IDA | GO:0030178 | negative regulation of Wnt signaling pathway |
BP | IEA | GO:0043615 | astrocyte cell migration |
Gene expression in normal tissue: APCDD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APCDD1
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APCDD1