CTNNA1


Summary: This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:116805
PHARMGKB IDPA27008
Map Location5q31.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in CTNNA1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0001669 acrosomal vesicle
CC IDA GO:0005794 Golgi apparatus
CC TAS GO:0005829 cytosol
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IDA GO:0005911 cell-cell junction
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Gene expression in normal tissue: CTNNA1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in CTNNA1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1500931 Cell-Cell communication
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194138 Signaling by VEGF
reactome R-HSA-194315 Signaling by Rho GTPases
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTNNA1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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