CTSB
Summary: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cathepsin B | MIM:116810 | Ensembl:ENSG00000164733 | HGNC:HGNC:2527 | PA27027 | 8p23.1 |
GO terms in CTSB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005518 | collagen binding |
| MF | IDA | GO:0008233 | peptidase activity |
| MF | IDA | GO:0008234 | cysteine-type peptidase activity |
| MF | IPI | GO:0043394 | proteoglycan binding |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IDA | GO:0030574 | collagen catabolic process |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0046697 | decidualization |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IEA | GO:0050790 | regulation of catalytic activity |
| BP | IBA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | IDA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | IEP | GO:0097067 | cellular response to thyroid hormone stimulus |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | ISS | GO:0005615 | extracellular space |
| CC | TAS | GO:0005622 | intracellular |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005764 | lysosome |
| CC | IDA | GO:0005764 | lysosome |
| CC | TAS | GO:0036021 | endolysosome lumen |
| CC | IEA | GO:0042470 | melanosome |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
Gene expression in normal tissue: CTSB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTSB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTSB
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