CNTN4


Summary: This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:607280
PHARMGKB IDPA26688
Map Location3p26.3-p26.2

Gene Categories:

DRUGGABLE GENOME

GO terms in CNTN4


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0007158 neuron cell-cell adhesion
BP IMP GO:0007399 nervous system development
BP TAS GO:0007409 axonogenesis
BP TAS GO:0007411 axon guidance
BP TAS GO:0007413 axonal fasciculation
BP ISS GO:0007420 brain development
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Gene expression in normal tissue: CNTN4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Protein stability and degradation1ERK MAPK signaling1

Pathways in CNTN4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-597592 Post-translational protein modification
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNTN4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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