DGKH
Summary: This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| diacylglycerol kinase eta | MIM:604071 | Ensembl:ENSG00000102780 | HGNC:HGNC:2854 | PA27315 | 13q14.11 |
Gene Categories:
KINASEGO terms in DGKH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003951 | NAD+ kinase activity |
| MF | IDA | GO:0004143 | diacylglycerol kinase activity |
| MF | IMP | GO:0004143 | diacylglycerol kinase activity |
| MF | TAS | GO:0004143 | diacylglycerol kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | IMP | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0016310 | phosphorylation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0046473 | phosphatidic acid metabolic process |
| BP | IMP | GO:0051259 | protein complex oligomerization |
Gene expression in normal tissue: DGKH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DGKH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DGKH
CLASSFICATION
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