Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008].

sprouty related EVH1 domain containing 1MIM:609291Ensembl:ENSG00000166068HGNC:HGNC:20249PA13489738215q14

GO terms in SPRED1

Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0005173stem cell factor receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding
MFIDAGO:0019902phosphatase binding
MFISSGO:0030291protein serine/threonine kinase inhibitor activity
CCTASGO:0005886plasma membrane
CCIDAGO:0031410cytoplasmic vesicle
BPTASGO:0000165MAPK cascade
BPISSGO:0000188inactivation of MAPK activity
BPIDAGO:0006469negative regulation of protein kinase activity
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPIMPGO:0010801negative regulation of peptidyl-threonine phosphorylation
BPIDAGO:0010923negative regulation of phosphatase activity
BPIMPGO:0016525negative regulation of angiogenesis
BPTASGO:0043408regulation of MAPK cascade
BPIMPGO:0043409negative regulation of MAPK cascade
BPISSGO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator
BPIMPGO:0060979vasculogenesis involved in coronary vascular morphogenesis
BPIEAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIEAGO:0090051negative regulation of cell migration involved in sprouting angiogenesis
BPISSGO:0090311regulation of protein deacetylation

Gene expression in normal tissue: SPRED1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPRED1

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5658442Regulation of RAS by GAPs
reactomeR-HSA-5658623FGFRL1 modulation of FGFR1 signaling
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPRED1