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DCK

Summary: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namedeoxycytidine kinase OMIM IDMIM:125450 Ensembl IDEnsembl:ENSG00000156136 HGNC IDHGNC:HGNC:2704 PHARMGKB IDPA137 Map Location4q13.3

Gene Categories:

METHYL TRANSFERASE KINASE DRUGGABLE GENOME

GO terms in DCK

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
BP	IDA	GO:0006220	pyrimidine nucleotide metabolic process
BP	IEA	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
BP	IEA	GO:0009165	nucleotide biosynthetic process

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Gene expression in normal tissue: DCK

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DCK

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Database	Pathway ID	Pathway Des.
kegg	hsa00230	Purine metabolism - Homo sapiens (human)
kegg	hsa00240	Pyrimidine metabolism - Homo sapiens (human)
pharmgkb	PA165860384	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkb	PA2036	Gemcitabine Pathway, Pharmacodynamics
humancyc	PWY-7199	pyrimidine deoxyribonucleosides salvage
humancyc	PWY-7200	superpathway of pyrimidine deoxyribonucleoside salvage

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DCK

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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