DCK
Summary: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| deoxycytidine kinase | MIM:125450 | Ensembl:ENSG00000156136 | HGNC:HGNC:2704 | PA137 | 4q13.3 |
GO terms in DCK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | IDA | GO:0006220 | pyrimidine nucleotide metabolic process |
| BP | IEA | GO:0009157 | deoxyribonucleoside monophosphate biosynthetic process |
| BP | IEA | GO:0009165 | nucleotide biosynthetic process |
| BP | IEA | GO:0016310 | phosphorylation |
| BP | TAS | GO:0043097 | pyrimidine nucleoside salvage |
| BP | TAS | GO:0043101 | purine-containing compound salvage |
| MF | IBA | GO:0004137 | deoxycytidine kinase activity |
| MF | IDA | GO:0004137 | deoxycytidine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008144 | drug binding |
| MF | IBA | GO:0019136 | deoxynucleoside kinase activity |
| MF | EXP | GO:0019206 | nucleoside kinase activity |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: DCK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DCK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| pharmgkb | PA165860384 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2036 | Gemcitabine Pathway, Pharmacodynamics |
| humancyc | PWY-7199 | pyrimidine deoxyribonucleosides salvage |
| humancyc | PWY-7200 | superpathway of pyrimidine deoxyribonucleoside salvage |
| humancyc | PWY-7224 | purine deoxyribonucleosides salvage |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP4022 | Pyrimidine metabolism |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
| smpdb | SMP00603 | Gemcitabine Metabolism Pathway |
| smpdb | SMP00649 | Lamivudine Metabolism Pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-73614 | Pyrimidine salvage |
| reactome | R-HSA-74217 | Purine salvage |
| reactome | R-HSA-8956321 | Nucleotide salvage |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DCK
CLASSFICATION
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