AKR1C1
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600449 Ensembl IDEnsembl:ENSG00000187134 HGNC IDHGNC:HGNC:384 PHARMGKB IDPA24677 Map Location10p15.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in AKR1C1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | NAS | GO:0006805 | xenobiotic metabolic process |
| BP | IDA | GO:0007586 | digestion |
| BP | IBA | GO:0008202 | steroid metabolic process |
| BP | IDA | GO:0008206 | bile acid metabolic process |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
Gene expression in normal tissue: AKR1C1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKR1C1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-192105 | Synthesis of bile acids and bile salts |
| reactome | R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| reactome | R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| reactome | R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKR1C1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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