AKR1C2
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600450 Ensembl IDEnsembl:ENSG00000151632 HGNC IDHGNC:HGNC:385 PHARMGKB IDPA24678 Map Location10p15.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in AKR1C2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | IDA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | IBA | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| MF | IBA | GO:0016229 | steroid dehydrogenase activity |
| MF | IBA | GO:0016491 | oxidoreductase activity |
| MF | IDA | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
Gene expression in normal tissue: AKR1C2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKR1C2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP696 | Benzo(a)pyrene metabolism |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| humancyc | PWY-7455 | allopregnanolone biosynthesis |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKR1C2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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