DDOST
Summary: This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | MIM:602202 | Ensembl:ENSG00000244038 | HGNC:HGNC:2728 | PA27195 | 1p36.12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in DDOST
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0008250 | oligosaccharyltransferase complex |
| CC | ISS | GO:0008250 | oligosaccharyltransferase complex |
| CC | TAS | GO:0008250 | oligosaccharyltransferase complex |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | TAS | GO:0035577 | azurophil granule membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | ISS | GO:0006486 | protein glycosylation |
| BP | IDA | GO:0006487 | protein N-linked glycosylation |
| BP | IBA | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | IC | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | IDA | GO:0034097 | response to cytokine |
| BP | IDA | GO:0042110 | T cell activation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| MF | ISS | GO:0004576 | oligosaccharyl transferase activity |
| MF | IBA | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| MF | IC | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| MF | IDA | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: DDOST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDOST
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-879415 | Advanced glycosylation endproduct receptor signaling |
| kegg | hsa00510 | N-Glycan biosynthesis - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| wikipathways | WP2324 | AGE-RAGE pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DDOST
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