DDX3X
Summary: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DEAD-box helicase 3 X-linked | MIM:300160 | Ensembl:ENSG00000215301 | HGNC:HGNC:2745 | PA27216 | Xp11.4 |
GO terms in DDX3X
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003924 | GTPase activity |
| MF | IDA | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | IDA | GO:0004004 | ATP-dependent RNA helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008143 | poly(A) binding |
| MF | IDA | GO:0008190 | eukaryotic initiation factor 4E binding |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IDA | GO:0017111 | nucleoside-triphosphatase activity |
| MF | IDA | GO:0031369 | translation initiation factor binding |
| MF | IDA | GO:0033592 | RNA strand annealing activity |
| MF | IDA | GO:0035613 | RNA stem-loop binding |
| MF | IDA | GO:0043024 | ribosomal small subunit binding |
| MF | IDA | GO:0043273 | CTPase activity |
| MF | IDA | GO:0043539 | protein serine/threonine kinase activator activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0048027 | mRNA 5'-UTR binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0006413 | translational initiation |
| BP | IMP | GO:0007059 | chromosome segregation |
| BP | IMP | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IDA | GO:0009615 | response to virus |
| BP | IDA | GO:0010501 | RNA secondary structure unwinding |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0016055 | Wnt signaling pathway |
| BP | IMP | GO:0017148 | negative regulation of translation |
| BP | IMP | GO:0030307 | positive regulation of cell growth |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | IDA | GO:0031333 | negative regulation of protein complex assembly |
| BP | IEA | GO:0032508 | DNA duplex unwinding |
| BP | TAS | GO:0032728 | positive regulation of interferon-beta production |
| BP | IDA | GO:0034063 | stress granule assembly |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0042256 | mature ribosome assembly |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IMP | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0045070 | positive regulation of viral genome replication |
| BP | IMP | GO:0045087 | innate immune response |
| BP | IDA | GO:0045727 | positive regulation of translation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045948 | positive regulation of translational initiation |
| BP | IDA | GO:0071243 | cellular response to arsenic-containing substance |
| BP | IDA | GO:0071470 | cellular response to osmotic stress |
| BP | TAS | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production |
| BP | IDA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0097193 | intrinsic apoptotic signaling pathway |
| BP | IMP | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| BP | IMP | GO:1903608 | protein localization to cytoplasmic stress granule |
| BP | IMP | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | IDA | GO:0010494 | cytoplasmic stress granule |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0022627 | cytosolic small ribosomal subunit |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
Gene expression in normal tissue: DDX3X
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDX3X
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DDX3X
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