DDX3X
Summary: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:300160 Ensembl IDEnsembl:ENSG00000215301 HGNC IDHGNC:HGNC:2745 PHARMGKB IDPA27216 Map LocationXp11.4 |
GO terms in DDX3X
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0003677 | DNA binding |
MF | HDA | GO:0003723 | RNA binding |
MF | IDA | GO:0003723 | RNA binding |
MF | IDA | GO:0003924 | GTPase activity |
MF | IDA | GO:0004003 | ATP-dependent DNA helicase activity |
MF | IDA | GO:0004004 | ATP-dependent RNA helicase activity |
Gene expression in normal tissue: DDX3X
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDX3X
Database | Pathway ID | Pathway Des. |
---|---|---|
netpath | Pathway_EGFR1 | EGFR1 |
netpath | Pathway_TCR | TCR |
netpath | Pathway_TNFalpha | TNFalpha |
kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD659 | Avagacestat (BMS-708163) | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in DDX3X
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |