DDX3X


Summary: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in DDX3X


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0003677 DNA binding
MF HDA GO:0003723 RNA binding
MF IDA GO:0003723 RNA binding
MF IDA GO:0003924 GTPase activity
MF IDA GO:0004003 ATP-dependent DNA helicase activity
MF IDA GO:0004004 ATP-dependent RNA helicase activity
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Gene expression in normal tissue: DDX3X

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 1

Gene-drug pathway distribution

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Pathways in DDX3X


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Database
Pathway ID
Pathway Des.
netpath Pathway_EGFR1 EGFR1
netpath Pathway_TCR TCR
netpath Pathway_TNFalpha TNFalpha
kegg hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegg hsa05161 Hepatitis B - Homo sapiens (human)
kegg hsa05203 Viral carcinogenesis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD659 Avagacestat (BMS-708163) 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX3X

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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