DHFR
Summary: Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:126060 Ensembl IDEnsembl:ENSG00000228716 HGNC IDHGNC:HGNC:2861 PHARMGKB IDPA143 Map Location5q14.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in DHFR
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000900 | translation repressor activity, mRNA regulatory element binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0004146 | dihydrofolate reductase activity |
| MF | IDA | GO:0004146 | dihydrofolate reductase activity |
| MF | ISS | GO:0004146 | dihydrofolate reductase activity |
| MF | NAS | GO:0004146 | dihydrofolate reductase activity |
Gene expression in normal tissue: DHFR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DHFR
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1601 | Fluoropyrimidine Activity |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP241 | One Carbon Metabolism |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2525 | Trans-sulfuration and one carbon metabolism |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DHFR
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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