NQO1
Summary: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:125860 Ensembl IDEnsembl:ENSG00000181019 HGNC IDHGNC:HGNC:2874 PHARMGKB IDPA31744 Map Location16q22.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in NQO1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity |
| MF | IEA | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity |
| MF | TAS | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H |
| MF | IEA | GO:0004784 | superoxide dismutase activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: NQO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NQO1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| pharmgkb | PA145011115 | Phenytoin Pathway, Pharmacokinetics |
| pharmgkb | PA150642262 | Platinum Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165292163 | Doxorubicin Pathway (Cancer Cell), Pharmacodynamics |
| pharmgkb | PA165292177 | Doxorubicin Pathway, Pharmacokinetics |
| kegg | hsa00130 | Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NQO1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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