SEPT1
Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
septin 1 | MIM:612897 | Ensembl:ENSG00000180096 | HGNC:HGNC:2879 | PA24354 | 16p11.2 |
GO terms in SEPT1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0003924 | GTPase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005525 | GTP binding |
MF | IBA | GO:0032947 | protein-containing complex scaffold activity |
MF | IPI | GO:0042802 | identical protein binding |
CC | IEA | GO:0005737 | cytoplasm |
CC | IEA | GO:0005815 | microtubule organizing center |
CC | IBA | GO:0005940 | septin ring |
CC | IBA | GO:0008021 | synaptic vesicle |
CC | IBA | GO:0015630 | microtubule cytoskeleton |
CC | IDA | GO:0030496 | midbody |
CC | IBA | GO:0031105 | septin complex |
CC | IBA | GO:0032153 | cell division site |
CC | IBA | GO:0032160 | septin filament array |
CC | IBA | GO:0043005 | neuron projection |
BP | IBA | GO:0000281 | mitotic cytokinesis |
BP | IBA | GO:0000921 | septin ring assembly |
BP | IEA | GO:0007049 | cell cycle |
BP | IBA | GO:0017157 | regulation of exocytosis |
BP | IBA | GO:0034613 | cellular protein localization |
BP | IEA | GO:0051301 | cell division |
BP | IBA | GO:0060271 | cilium assembly |
Gene expression in normal tissue: SEPT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEPT1
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | aurora_b_pathway | Aurora B signaling |
kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEPT1