SEPT1

Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameseptin 1
OMIM IDMIM:612897
Ensembl IDEnsembl:ENSG00000180096
HGNC IDHGNC:HGNC:2879
PHARMGKB IDPA24354
Map Location16p11.2

GO terms in SEPT1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0003924 GTPase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005525 GTP binding
MF IBA GO:0032947 protein-containing complex scaffold activity
MF IPI GO:0042802 identical protein binding
CC IEA GO:0005737 cytoplasm
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Gene expression in normal tissue: SEPT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEPT1


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Database
Pathway ID
Pathway Des.
pid aurora_b_pathway Aurora B signaling
kegg hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEPT1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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