SEPT1


Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
septin 1MIM:612897Ensembl:ENSG00000180096HGNC:HGNC:2879PA2435416p11.2

GO terms in SEPT1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIBAGO:0032947protein-containing complex scaffold activity
MFIPIGO:0042802identical protein binding
CCIEAGO:0005737cytoplasm
CCIEAGO:0005815microtubule organizing center
CCIBAGO:0005940septin ring
CCIBAGO:0008021synaptic vesicle
CCIBAGO:0015630microtubule cytoskeleton
CCIDAGO:0030496midbody
CCIBAGO:0031105septin complex
CCIBAGO:0032153cell division site
CCIBAGO:0032160septin filament array
CCIBAGO:0043005neuron projection
BPIBAGO:0000281mitotic cytokinesis
BPIBAGO:0000921septin ring assembly
BPIEAGO:0007049cell cycle
BPIBAGO:0017157regulation of exocytosis
BPIBAGO:0034613cellular protein localization
BPIEAGO:0051301cell division
BPIBAGO:0060271cilium assembly

Gene expression in normal tissue: SEPT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEPT1


DatabasePathway IDPathway Des.
pidaurora_b_pathwayAurora B signaling
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEPT1

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