DLG1
Summary: This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| discs large MAGUK scaffold protein 1 | MIM:601014 | Ensembl:ENSG00000075711 | HGNC:HGNC:2900 | PA27356 | 3q29 |
GO terms in DLG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004385 | guanylate kinase activity |
| MF | TAS | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | TAS | GO:0008092 | cytoskeletal protein binding |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IDA | GO:0015459 | potassium channel regulator activity |
| MF | ISS | GO:0015459 | potassium channel regulator activity |
| MF | NAS | GO:0015459 | potassium channel regulator activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019902 | phosphatase binding |
| MF | IPI | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IEA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IBA | GO:0035255 | ionotropic glutamate receptor binding |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0097016 | L27 domain binding |
| CC | IDA | GO:0001772 | immunological synapse |
| CC | TAS | GO:0001772 | immunological synapse |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005874 | microtubule |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0005923 | bicellular tight junction |
| CC | IBA | GO:0008328 | ionotropic glutamate receptor complex |
| CC | IDA | GO:0009898 | cytoplasmic side of plasma membrane |
| CC | TAS | GO:0014704 | intercalated disc |
| CC | IBA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0016328 | lateral plasma membrane |
| CC | IBA | GO:0030054 | cell junction |
| CC | IDA | GO:0030054 | cell junction |
| CC | IEA | GO:0031253 | cell projection membrane |
| CC | IBA | GO:0031594 | neuromuscular junction |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | IEA | GO:0033268 | node of Ranvier |
| CC | IEA | GO:0035748 | myelin sheath abaxonal region |
| CC | IEA | GO:0042383 | sarcolemma |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IEA | GO:0043219 | lateral loop |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0097025 | MPP7-DLG1-LIN7 complex |
| CC | IBA | GO:0098839 | postsynaptic density membrane |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IEA | GO:0001771 | immunological synapse formation |
| BP | IDA | GO:0001935 | endothelial cell proliferation |
| BP | IEA | GO:0002088 | lens development in camera-type eye |
| BP | IEA | GO:0002369 | T cell cytokine production |
| BP | IEA | GO:0006470 | protein dephosphorylation |
| BP | IDA | GO:0007015 | actin filament organization |
| BP | NAS | GO:0007093 | mitotic cell cycle checkpoint |
| BP | TAS | GO:0007163 | establishment or maintenance of cell polarity |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0030432 | peristalsis |
| BP | IEA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IDA | GO:0030866 | cortical actin cytoskeleton organization |
| BP | IMP | GO:0030953 | astral microtubule organization |
| BP | IEA | GO:0031579 | membrane raft organization |
| BP | IEA | GO:0031641 | regulation of myelination |
| BP | IEA | GO:0032147 | activation of protein kinase activity |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IMP | GO:0034629 | cellular protein-containing complex localization |
| BP | IEA | GO:0042110 | T cell activation |
| BP | IEA | GO:0042130 | negative regulation of T cell proliferation |
| BP | IDA | GO:0042391 | regulation of membrane potential |
| BP | IEA | GO:0042982 | amyloid precursor protein metabolic process |
| BP | IBA | GO:0043113 | receptor clustering |
| BP | IDA | GO:0043268 | positive regulation of potassium ion transport |
| BP | IMP | GO:0043622 | cortical microtubule organization |
| BP | IBA | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| BP | IMP | GO:0045930 | negative regulation of mitotic cell cycle |
| BP | IEA | GO:0046037 | GMP metabolic process |
| BP | IEA | GO:0046710 | GDP metabolic process |
| BP | IEA | GO:0048608 | reproductive structure development |
| BP | IEA | GO:0048704 | embryonic skeletal system morphogenesis |
| BP | IEA | GO:0048745 | smooth muscle tissue development |
| BP | IEA | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IMP | GO:0051660 | establishment of centrosome localization |
| BP | IEA | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IEA | GO:0060022 | hard palate development |
| BP | IMP | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070830 | bicellular tight junction assembly |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | TAS | GO:0072659 | protein localization to plasma membrane |
| BP | IBA | GO:0097120 | receptor localization to synapse |
| BP | IDA | GO:0098609 | cell-cell adhesion |
| BP | ISS | GO:0098911 | regulation of ventricular cardiac muscle cell action potential |
| BP | IMP | GO:1901222 | regulation of NIK/NF-kappaB signaling |
| BP | TAS | GO:1902305 | regulation of sodium ion transmembrane transport |
| BP | IDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | ISS | GO:1903286 | regulation of potassium ion import |
| BP | IMP | GO:1903753 | negative regulation of p38MAPK cascade |
| BP | ISS | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| BP | ISS | GO:1903764 | regulation of potassium ion export across plasma membrane |
Gene expression in normal tissue: DLG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DLG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-447038 | NrCAM interactions |
| reactome | R-HSA-451306 | Ionotropic activity of kainate receptors |
| reactome | R-HSA-451308 | Activation of Ca-permeable Kainate Receptor |
| reactome | R-HSA-451326 | Activation of kainate receptors upon glutamate binding |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-8849932 | Synaptic adhesion-like molecules |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DLG1
CLASSFICATION
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