DUSP3
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual specificity phosphatase 3 | MIM:600183 | Ensembl:ENSG00000108861 | HGNC:HGNC:3069 | PA27526 | 17q21.31 |
GO terms in DUSP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001772 | immunological synapse |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| BP | IMP | GO:0000188 | inactivation of MAPK activity |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IDA | GO:0016311 | dephosphorylation |
| BP | IDA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IMP | GO:0043409 | negative regulation of MAPK cascade |
| BP | IBA | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IBA | GO:0046329 | negative regulation of JNK cascade |
| BP | IDA | GO:0046329 | negative regulation of JNK cascade |
| BP | IMP | GO:0046329 | negative regulation of JNK cascade |
| BP | IBA | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| BP | IDA | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| BP | IBA | GO:0050868 | negative regulation of T cell activation |
| BP | IDA | GO:0050868 | negative regulation of T cell activation |
| BP | IBA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | TAS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IDA | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| MF | IMP | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| MF | IDA | GO:0016791 | phosphatase activity |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0033549 | MAP kinase phosphatase activity |
| MF | IMP | GO:0033549 | MAP kinase phosphatase activity |
Gene expression in normal tissue: DUSP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DUSP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TCR | TCR |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| wikipathways | WP382 | MAPK Signaling Pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-202670 | ERKs are inactivated |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DUSP3
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