Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008].

dual specificity phosphatase 5MIM:603069Ensembl:ENSG00000138166HGNC:HGNC:3071PA2752810q25.2

GO terms in DUSP5

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPTASGO:0000187activation of MAPK activity
BPIBAGO:0000188inactivation of MAPK activity
BPIEAGO:0000188inactivation of MAPK activity
BPTASGO:0006470protein dephosphorylation
BPIDAGO:0035335peptidyl-tyrosine dephosphorylation
BPIDAGO:0035970peptidyl-threonine dephosphorylation
MFIEAGO:0004725protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIBAGO:0008138protein tyrosine/serine/threonine phosphatase activity
MFIDAGO:0008138protein tyrosine/serine/threonine phosphatase activity
MFTASGO:0008138protein tyrosine/serine/threonine phosphatase activity
MFIDAGO:0016791phosphatase activity
MFIBAGO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity
MFIEAGO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity

Gene expression in normal tissue: DUSP5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DUSP5

DatabasePathway IDPathway Des.
wikipathwaysWP2853Endoderm Differentiation
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
pidatf2_pathwayATF-2 transcription factor network
pidp53downstreampathwayDirect p53 effectors
reactomeR-HSA-112409RAF-independent MAPK1/3 activation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DUSP5