DUSP5
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual specificity phosphatase 5 | MIM:603069 | Ensembl:ENSG00000138166 | HGNC:HGNC:3071 | PA27528 | 10q25.2 |
GO terms in DUSP5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IBA | GO:0000188 | inactivation of MAPK activity |
| BP | IEA | GO:0000188 | inactivation of MAPK activity |
| BP | TAS | GO:0006470 | protein dephosphorylation |
| BP | IDA | GO:0016311 | dephosphorylation |
| BP | IDA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IDA | GO:0035970 | peptidyl-threonine dephosphorylation |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| MF | IEA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| MF | IDA | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| MF | TAS | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| MF | IDA | GO:0016791 | phosphatase activity |
| MF | IBA | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity |
| MF | IEA | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity |
Gene expression in normal tissue: DUSP5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DUSP5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2853 | Endoderm Differentiation |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | p53downstreampathway | Direct p53 effectors |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5675221 | Negative regulation of MAPK pathway |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DUSP5
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