DUSP6
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual specificity phosphatase 6 | MIM:602748 | Ensembl:ENSG00000139318 | HGNC:HGNC:3072 | PA27529 | 12q21.33 |
GO terms in DUSP6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IDA | GO:0000188 | inactivation of MAPK activity |
| BP | IBA | GO:0006470 | protein dephosphorylation |
| BP | IBA | GO:0009953 | dorsal/ventral pattern formation |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IBA | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0042493 | response to drug |
| BP | IBA | GO:0042663 | regulation of endodermal cell fate specification |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEP | GO:0051409 | response to nitrosative stress |
| BP | IBA | GO:0060420 | regulation of heart growth |
| BP | IBA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0070848 | response to growth factor |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | TAS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IBA | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| MF | TAS | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| MF | IBA | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity |
| MF | IDA | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity |
Gene expression in normal tissue: DUSP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DUSP6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | fgf_pathway | FGF signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| wikipathways | WP382 | MAPK Signaling Pathway |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-202670 | ERKs are inactivated |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5675221 | Negative regulation of MAPK pathway |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | dsppathway | regulation of map kinase pathways through dual specificity phosphatases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD52 | Rotenone | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD188 | Piperlongumine | 7 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD446 | LY 2183240 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DUSP6
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