DUT
Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| deoxyuridine triphosphatase | MIM:601266 | Ensembl:ENSG00000128951 | HGNC:HGNC:3078 | PA151 | 15q21.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in DUT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000287 | magnesium ion binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | EXP | GO:0004170 | dUTP diphosphatase activity |
| MF | IBA | GO:0004170 | dUTP diphosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0006139 | nucleobase-containing compound metabolic process |
| BP | IBA | GO:0006226 | dUMP biosynthetic process |
| BP | IEA | GO:0006226 | dUMP biosynthetic process |
| BP | TAS | GO:0006260 | DNA replication |
| BP | TAS | GO:0015949 | nucleobase-containing small molecule interconversion |
| BP | IBA | GO:0046081 | dUTP catabolic process |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: DUT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DUT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-499943 | Interconversion of nucleotide di- and triphosphates |
| smpdb | SMP00046 | Pyrimidine Metabolism |
| smpdb | SMP00172 | Beta Ureidopropionase Deficiency |
| smpdb | SMP00178 | Dihydropyrimidinase Deficiency |
| smpdb | SMP00202 | MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) |
| smpdb | SMP00219 | UMP Synthase Deiciency (Orotic Aciduria) |
| wikipathways | WP4022 | Pyrimidine metabolism |
| humancyc | PWY-7184 | pyrimidine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7211 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DUT
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