Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008].

E2F transcription factor 2MIM:600426Ensembl:ENSG00000007968HGNC:HGNC:3114PA275721p36.12

GO terms in E2F2

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0000987proximal promoter sequence-specific DNA binding
MFICGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFNASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0043565sequence-specific DNA binding
MFIEAGO:0046983protein dimerization activity
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIEAGO:0007049cell cycle
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051726regulation of cell cycle
BPIEAGO:0072332intrinsic apoptotic signaling pathway by p53 class mediator
BPIGIGO:1903671negative regulation of sprouting angiogenesis
BPIEAGO:1990086lens fiber cell apoptotic process
CCIDAGO:0090575RNA polymerase II transcription factor complex

Gene expression in normal tissue: E2F2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in E2F2

DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-68689CDC6 association with the ORC:origin complex
reactomeR-HSA-68867Assembly of the pre-replicative complex
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-8953897Cellular responses to external stimuli
wikipathwaysWP179Cell Cycle
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP45G1 to S cell cycle control
pide2f_pathwayE2F transcription factor network
pidp53downstreampathwayDirect p53 effectors
pidrb_1pathwayRegulation of retinoblastoma protein
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in E2F2