E4F1
Summary: The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| E4F transcription factor 1 | MIM:603022 | Ensembl:ENSG00000167967 | HGNC:HGNC:3121 | PA27579 | 16p13.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in E4F1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016740 | transferase activity |
| MF | IDA | GO:0035497 | cAMP response element binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005819 | spindle |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0009794 | regulation of mitotic cell cycle, embryonic |
| BP | IDA | GO:0010564 | regulation of cell cycle process |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:0071850 | mitotic cell cycle arrest |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
Gene expression in normal tissue: E4F1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in E4F1
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