EDNRB


Summary: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
endothelin receptor type BMIM:131244Ensembl:ENSG00000136160HGNC:HGNC:3180PA2761813q22.3

GO terms in EDNRB


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004962endothelin receptor activity
MFIMPGO:0004962endothelin receptor activity
MFIPIGO:0005515protein binding
MFIPIGO:0017046peptide hormone binding
MFIEAGO:0031702type 1 angiotensin receptor binding
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0031965nuclear membrane
CCIEAGO:0045121membrane raft
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001755neural crest cell migration
BPIEAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0006885regulation of pH
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007194negative regulation of adenylate cyclase activity
BPIEAGO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway
BPIEAGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0007399nervous system development
BPIEAGO:0007422peripheral nervous system development
BPIEAGO:0007497posterior midgut development
BPIEAGO:0007568aging
BPIEAGO:0008217regulation of blood pressure
BPIEAGO:0008284positive regulation of cell proliferation
BPISSGO:0014043negative regulation of neuron maturation
BPIEAGO:0014070response to organic cyclic compound
BPIMPGO:0014826vein smooth muscle contraction
BPIEAGO:0019233sensory perception of pain
BPIMPGO:0019722calcium-mediated signaling
BPIEAGO:0019934cGMP-mediated signaling
BPIEAGO:0030318melanocyte differentiation
BPIEAGO:0031620regulation of fever generation
BPIMPGO:0032269negative regulation of cellular protein metabolic process
BPISSGO:0035645enteric smooth muscle cell differentiation
BPIEAGO:0035810positive regulation of urine volume
BPIEAGO:0035815positive regulation of renal sodium excretion
BPIEAGO:0042045epithelial fluid transport
BPIMPGO:0042310vasoconstriction
BPIEAGO:0042311vasodilation
BPIEAGO:0043066negative regulation of apoptotic process
BPIMPGO:0048246macrophage chemotaxis
BPIEAGO:0048265response to pain
BPISSGO:0048484enteric nervous system development
BPIEAGO:0050678regulation of epithelial cell proliferation
BPIEAGO:0051930regulation of sensory perception of pain
BPIEAGO:0060406positive regulation of penile erection
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIDAGO:0086100endothelin receptor signaling pathway
BPIMPGO:0086100endothelin receptor signaling pathway
BPIEAGO:1990839response to endothelin

Gene expression in normal tissue: EDNRB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EDNRB


DatabasePathway IDPathway Des.
wikipathwaysWP2197Endothelin Pathways
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP98Prostaglandin Synthesis and Regulation
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pidendothelinpathwayEndothelins
biocartabarrestinpathway-arrestins in gpcr desensitization
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartaraccpathwayion channels and their functional role in vascular endothelium
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD64Parbendazole3
iGMDRD871BRD63683
iGMDRD188Piperlongumine3
iGMDRD68Paclitaxel1
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD137Indisulam3
iGMDRD138PX 123
iGMDRD121GMX17783
iGMDRD202Curcumin3
iGMDRD158NSC1415406
iGMDRD255SB2250023
iGMDRD123Isoevodiamine6
iGMDRD901ELCPK3
iGMDRD446LY 21832404
iGMDRD532Olaparib3
iGMDRD79Gemcitabine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EDNRB

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