EDNRB
Summary: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endothelin receptor type B | MIM:131244 | Ensembl:ENSG00000136160 | HGNC:HGNC:3180 | PA27618 | 13q22.3 |
GO terms in EDNRB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004962 | endothelin receptor activity |
| MF | IMP | GO:0004962 | endothelin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017046 | peptide hormone binding |
| MF | IEA | GO:0031702 | type 1 angiotensin receptor binding |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0031965 | nuclear membrane |
| CC | IEA | GO:0045121 | membrane raft |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001755 | neural crest cell migration |
| BP | IEA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0006885 | regulation of pH |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007194 | negative regulation of adenylate cyclase activity |
| BP | IEA | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IEA | GO:0007422 | peripheral nervous system development |
| BP | IEA | GO:0007497 | posterior midgut development |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0008217 | regulation of blood pressure |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0014043 | negative regulation of neuron maturation |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IMP | GO:0014826 | vein smooth muscle contraction |
| BP | IEA | GO:0019233 | sensory perception of pain |
| BP | IMP | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0019934 | cGMP-mediated signaling |
| BP | IEA | GO:0030318 | melanocyte differentiation |
| BP | IEA | GO:0031620 | regulation of fever generation |
| BP | IMP | GO:0032269 | negative regulation of cellular protein metabolic process |
| BP | ISS | GO:0035645 | enteric smooth muscle cell differentiation |
| BP | IEA | GO:0035810 | positive regulation of urine volume |
| BP | IEA | GO:0035815 | positive regulation of renal sodium excretion |
| BP | IEA | GO:0042045 | epithelial fluid transport |
| BP | IMP | GO:0042310 | vasoconstriction |
| BP | IEA | GO:0042311 | vasodilation |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0048246 | macrophage chemotaxis |
| BP | IEA | GO:0048265 | response to pain |
| BP | ISS | GO:0048484 | enteric nervous system development |
| BP | IEA | GO:0050678 | regulation of epithelial cell proliferation |
| BP | IEA | GO:0051930 | regulation of sensory perception of pain |
| BP | IEA | GO:0060406 | positive regulation of penile erection |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0086100 | endothelin receptor signaling pathway |
| BP | IMP | GO:0086100 | endothelin receptor signaling pathway |
| BP | IEA | GO:1990839 | response to endothelin |
Gene expression in normal tissue: EDNRB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EDNRB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2197 | Endothelin Pathways |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| pid | endothelinpathway | Endothelins |
| biocarta | barrestinpathway | -arrestins in gpcr desensitization |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD79 | Gemcitabine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EDNRB
CLASSFICATION
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