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EDNRB

Summary: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameendothelin receptor type B OMIM IDMIM:131244 Ensembl IDEnsembl:ENSG00000136160 HGNC IDHGNC:HGNC:3180 PHARMGKB IDPA27618 Map Location13q22.3

Gene Categories:

G PROTEIN COUPLED RECEPTOR DRUGGABLE GENOME

GO terms in EDNRB

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004962	endothelin receptor activity
MF	IMP	GO:0004962	endothelin receptor activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0017046	peptide hormone binding
MF	IEA	GO:0031702	type 1 angiotensin receptor binding
CC	IDA	GO:0005886	plasma membrane

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Gene expression in normal tissue: EDNRB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EDNRB

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Database	Pathway ID	Pathway Des.
wikipathways	WP2197	Endothelin Pathways
wikipathways	WP24	Peptide GPCRs
wikipathways	WP455	GPCRs, Class A Rhodopsin-like
wikipathways	WP98	Prostaglandin Synthesis and Regulation
kegg	hsa04020	Calcium signaling pathway - Homo sapiens (human)
kegg	hsa04022	cGMP-PKG signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD64	Parbendazole	3
iGMDRD871	BRD6368	3
iGMDRD188	Piperlongumine	3
iGMDRD68	Paclitaxel	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EDNRB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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