AGO3
Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| argonaute 3, RISC catalytic component | MIM:607355 | Ensembl:ENSG00000126070 | HGNC:HGNC:18421 | PA38329 | 1p34.3 |
GO terms in AGO3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | IDA | GO:0003727 | single-stranded RNA binding |
| MF | IMP | GO:0004521 | endoribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035198 | miRNA binding |
| MF | IMP | GO:0090624 | endoribonuclease activity, cleaving miRNA-paired mRNA |
| BP | IDA | GO:0006402 | mRNA catabolic process |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | IDA | GO:0010501 | RNA secondary structure unwinding |
| BP | IMP | GO:0010501 | RNA secondary structure unwinding |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0031054 | pre-miRNA processing |
| BP | TAS | GO:0035194 | posttranscriptional gene silencing by RNA |
| BP | IMP | GO:0035196 | production of miRNAs involved in gene silencing by miRNA |
| BP | IDA | GO:0035278 | miRNA mediated inhibition of translation |
| BP | IDA | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA |
| BP | IDA | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IMP | GO:0072091 | regulation of stem cell proliferation |
| BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
| BP | IDA | GO:0090625 | mRNA cleavage involved in gene silencing by siRNA |
| BP | IEA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| CC | IEA | GO:0000794 | condensed nuclear chromosome |
| CC | IEA | GO:0000932 | P-body |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016442 | RISC complex |
| CC | IEA | GO:0035068 | micro-ribonucleoprotein complex |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| CC | IDA | GO:0070578 | RISC-loading complex |
Gene expression in normal tissue: AGO3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGO3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-203927 | MicroRNA (miRNA) biogenesis |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-426486 | Small interfering RNA (siRNA) biogenesis |
| reactome | R-HSA-426496 | Post-transcriptional silencing by small RNAs |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934593 | Regulation of RUNX1 Expression and Activity |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8943723 | Regulation of PTEN mRNA translation |
| reactome | R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGO3
CLASSFICATION
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