AGO3
Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607355 Ensembl IDEnsembl:ENSG00000126070 HGNC IDHGNC:HGNC:18421 PHARMGKB IDPA38329 Map Location1p34.3 | |||||
GO terms in AGO3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | IDA | GO:0003727 | single-stranded RNA binding |
| MF | IMP | GO:0004521 | endoribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035198 | miRNA binding |
Gene expression in normal tissue: AGO3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGO3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGO3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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