EFNB3


Summary: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602297
PHARMGKB IDPA27663
Map Location17p13.1

GO terms in EFNB3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0007267 cell-cell signaling
BP TAS GO:0007399 nervous system development
BP IBA GO:0007411 axon guidance
BP IEA GO:0007628 adult walking behavior
BP IEA GO:0016198 axon choice point recognition
BP IEA GO:0018108 peptidyl-tyrosine phosphorylation
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Gene expression in normal tissue: EFNB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EFNB3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-3928662 EPHB-mediated forward signaling
reactome R-HSA-3928662 EPHB-mediated forward signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EFNB3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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