EFNB3
Summary: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Nameephrin B3 OMIM IDMIM:602297 Ensembl IDEnsembl:ENSG00000108947 HGNC IDHGNC:HGNC:3228 PHARMGKB IDPA27663 Map Location17p13.1 |
GO terms in EFNB3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0007267 | cell-cell signaling |
BP | TAS | GO:0007399 | nervous system development |
BP | IBA | GO:0007411 | axon guidance |
BP | IEA | GO:0007628 | adult walking behavior |
BP | IEA | GO:0016198 | axon choice point recognition |
BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
Gene expression in normal tissue: EFNB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EFNB3
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in EFNB3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |